carcinoma
Nasopharyngeal Carcinoma Risk Genes Identified, Characterized
Using association, regulatory, and functional analyses coupled with cell line experiments, researchers characterized new nasopharyngeal cancer risk genes.
Cervical Cancer Exomes Point to Potentially Targetable HER, PIK3CA Pathway Changes
Exome sequences from dozens of cervical cancer tumor or primary cell line samples revealed recurrent alterations affecting ERBB2/HER2 and PIK3CA pathways.
A Phase II trial is pursuing molecularly targeted treatments for CUP as a different Phase III trial failed to find benefit for expression-based primary site therapies.
Using 10x Genomics' immune profiling and ATAC-seq assays, the researchers upended the notion that cancer-fighting T cells come from within a tumor.
Checkpoint Immunotherapy Response Described in Tumors with Gene Fusion-Based Neoantigens
Starting with a head and neck cancer patient who showed an impressive response to pembrolizumab, researchers profiled gene fusion neoantigens in several tumor types.