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LGC Clinical Diagnostics Seraseq 22q11 Female-Matched Reference Material

LGC Clinical Diagnostics has launched its 22q11 Female-Matched Reference Material, part of the company's Seraseq noninvasive prenatal testing (NIPT) portfolio. The reference material can be used to develop a new test, validate an assay, monitor routine performance, troubleshoot problems across a workflow, and ensure overall proficiency. It is compatible with a broad range of NIPT assay methods, and uses a proprietary method that maintains native cell-free DNA characteristics such as a size profile of about 170 bp, size distribution, SNP content, and natural maternal-fetal size difference, LGC said.

The Scan

Cystatin C Plays Role in Immunosuppression, Cancer Immunotherapy Failure, Study Finds

A study in Cell Genomics provides insight into how glucocorticoids can lead to cancer immunotherapy failure via cystatin C production.

Aging, Species Lifespan Gene Expression Signatures Overlap

An Osaka Metropolitan University team reports in Nucleic Acids Research that transcriptional signatures of aging and maximum lifespan have similarities.

Splicing Subgroup Provides Protocols for Evaluating Splicing Variant Data

The group presents their approach on how to apply evidence codes to splicing predictions and other data in the American Journal of Human Genetics.

Single-Cell Transcriptomic Atlas of Mouse Cochlea to Aid Treatment Development

Researchers in PNAS conducted single-cell and single-nuclear sequencing of about 120,000 cells at three key timepoints in cochlear development to generate a transcriptomic atlas.